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. 2024 Jul 8;16(8):1930–1956. doi: 10.1038/s44321-024-00096-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

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(A, B) Statistical analysis of RVSP (A) and heart rate (B) in mice treated with the solvent DMSO or FR (10 µg/mouse i.p., Monday to Friday) during exposure to Nx (DMSO: n = 8, FR: n = 7) or SuHx, (10% O₂, DMSO: n = 10, FR: n = 10) for 3 weeks. (C, D) H&E-staining of lung sections from SuHx-DMSO (C) and SuHx-FR-treated mice (D), scale bar: 20 µm. (E, F) Statistical analysis of vascular wall thickness in mice treated with the solvent DMSO or FR during exposure to Nx (DMSO: n = 8, FR: n = 7) or SuHx (DMSO: n = 10, FR: n = 10) (E) and ratio of the media/CSA of small (30–50 µm), medium-sized (50–70 µm) and large (70–150 µm) PAs of mice exposed to SuHx for 3 weeks (DMSO: n = 10, FR: n = 10) (F). (G, H) WGA staining of transversal heart sections from right ventricles of SuHx-DMSO (G) and SuHx-FR-treated mice (H), scale bar: 20 µm. (I) Statistical analysis of right ventricular cardiomyocyte cross sectional area in mice treated with DMSO or FR during exposure to Nx (DMSO: n = 8, FR: n = 7) or SuHx (DMSO: n = 10, FR: n = 8). Data information: Values are expressed as mean ± SEM. (A, B, E, I) One-way ANOVA, Tukey’s post hoc test, (F) Two-way ANOVA, Bonferroni post hoc test. Source data are available online for this figure.