Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jul 8;16(8):1930–1956. doi: 10.1038/s44321-024-00096-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

PMC Copyright notice

(A, B) Statistical analysis of RVSP (A) and heart rate (B) in mice treated with the solvent DMSO (n = 9) or FR (10 µg/mouse i.p., Monday to Friday, n = 9) in the last 2 weeks of 5 weeks SuHx (10% O₂) exposure. (C, D) H&E-staining of lung sections from SuHx-DMSO (C) and SuHx-FR-treated mice (D), scale bar: 20 µm. (E–G) Statistical analysis of vascular wall thickness in mice treated with the solvent DMSO or FR during exposure SuHx (DMSO: n = 9, FR: n = 9) (E), ratio of media/CSA of small (30–50 µm), medium-sized (50–70 µm) and large (70–150 µm) PAs of mice exposed to SuHx (DMSO: n = 9, FR: n = 9) and muscularization of PAs (30–70 µm) of mice exposed to SuHx (DMSO: n = 9, FR: n = 9) (G). (H) Statistical analysis of macrophage infiltration in mice treated with the solvent DMSO or FR during SuHx exposure (DMSO: n = 9, FR: n = 9). (I) Statistical analysis of Fulton index in mice treated with the solvent DMSO or FR during SuHx exposure (DMSO: n = 7, FR: n = 5). (J, K) WGA staining of transversal heart sections from right ventricles of SuHx-DMSO (J) and SuHx-FR-treated mice (K), scale bar: 20 µm. (L) Statistical analysis of right ventricular cardiomyocyte cross sectional area in mice treated with DMSO (n = 9) or FR (n = 9) during exposure to SuHx. (M, N) Representative M-mode pictures of SuHx-DMSO (M) and SuHx-FR-treated mice (N) displaying diastolic right ventricular wall thickness (RVWT, d) during echocardiography. (O) Statistical analysis of RVWT, d in mice treated with DMSO (n = 7) or FR (n = 7) during exposure to SuHx. Data information: Values are expressed as mean ± SEM. (A, B, E, H, I, L, O) Unpaired student’s t-test, (F, G) Two-way ANOVA, Bonferroni post hoc test. Source data are available online for this figure.