Fig. 4. No significant associations between longitudinal changes in cortical structure (acAN-TP2-acAN-TP1) and changes in serum concentrations of the TNF-α cytokine.

Left: Associations with CT changes. Right: Associations with lGI changes. Uncorrected statistical maps (p < 0.05) plotted on the inflated surface of the standard average subject and displaying regions in which differences in CT or lGI between acAN-TP2 and acAN-TP1 were associated with changes in TNF-α. The color scale shows p values expressed as −log₁₀(p). Warm colors indicate a positive correlation between changes in TNF-α and CT or lGI. After FDR-correcting for multiple comparisons (q < 0.05) across each hemisphere and Bonferroni correcting across cytokine type, these associations were not significant. LH left hemisphere, RH right hemisphere. Colored outlines correspond to anatomical labels of the Desikan-Killiany atlas [44].