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. 2024 Jul 26;13(7):3783–3797. doi: 10.21037/tcr-24-747

Table 2. Summary of PFS and OS rate.

Author, year Outcomes Intervention 1 Intervention 2 RR (95% CI)
Regimen Rate, % Total patients Regimen Rate, % Total patients
NCT00481247 (18) 5-year PFS rate DAS 100 mg 88.80 259 IM 400 mg 89.23 260 1.00 (0.94–1.06)
Li, 2021 (22) 3-year PFS rate NIL 300–400 mg 87.18 39 IM 400 mg 66.64 39 1.31 (1.02–1.68)
Jabbour, 2014 (19) 3-year PFS rate DAS 100 mg 91.11 259 IM 400 mg 90.77 260 1.00 (0.95–1.06)
Kantarjian, 2012 (20) 2-year PFS rate DAS 100 mg 93.82 259 IM 400 mg 91.92 260 1.02 (0.98–1.05)a
Cortes, 2020 (25) 2-year PFS rate DAS 100 mg 95.98 174 IM 400 mg 95.35 86
Brümmendorf, 2022 (16) 5-year OS rate BOS 400 mg 94.31 246 IM 400 mg 94.61 241 1.00 (0.95–1.04)
NCT00481247 (18) 5-year OS rate DAS 100 mg 90.73 259 IM 400 mg 89.61 260 1.01 (0.96–1.07)
Li, 2021 (22) 3-year OS rate NIL 300–400 mg 92.31 39 IM 400 mg 79.49 39 1.16 (0.97–1.40)
Jabbour, 2014 (19) 3-year OS rate DAS 100 mg 93.82 259 IM 400 mg 93.08 260 1.01 (0.96–1.05)
Kantarjian, 2012 (20) 2-year OS rate DAS 100 mg 95.37 259 IM 400 mg 95.38 260 1.00 (0.97–1.03)a
Cortes, 2020 (25) 2-year OS rate DAS 100 mg 97.70 174 IM 400 mg 96.51 86

a, RR reflects the pooled effect size through the meta-analysis. PFS, progression-free survival; OS, overall survival; RR, risk ratios; IM, imatinib; DAS, dasatinib; NIL, nilotinib; BOS, bosutinib.