Table 2. Summary of PFS and OS rate.
Author, year | Outcomes | Intervention 1 | Intervention 2 | RR (95% CI) | |||||
---|---|---|---|---|---|---|---|---|---|
Regimen | Rate, % | Total patients | Regimen | Rate, % | Total patients | ||||
NCT00481247 (18) | 5-year PFS rate | DAS 100 mg | 88.80 | 259 | IM 400 mg | 89.23 | 260 | 1.00 (0.94–1.06) | |
Li, 2021 (22) | 3-year PFS rate | NIL 300–400 mg | 87.18 | 39 | IM 400 mg | 66.64 | 39 | 1.31 (1.02–1.68) | |
Jabbour, 2014 (19) | 3-year PFS rate | DAS 100 mg | 91.11 | 259 | IM 400 mg | 90.77 | 260 | 1.00 (0.95–1.06) | |
Kantarjian, 2012 (20) | 2-year PFS rate | DAS 100 mg | 93.82 | 259 | IM 400 mg | 91.92 | 260 | 1.02 (0.98–1.05)a | |
Cortes, 2020 (25) | 2-year PFS rate | DAS 100 mg | 95.98 | 174 | IM 400 mg | 95.35 | 86 | ||
Brümmendorf, 2022 (16) | 5-year OS rate | BOS 400 mg | 94.31 | 246 | IM 400 mg | 94.61 | 241 | 1.00 (0.95–1.04) | |
NCT00481247 (18) | 5-year OS rate | DAS 100 mg | 90.73 | 259 | IM 400 mg | 89.61 | 260 | 1.01 (0.96–1.07) | |
Li, 2021 (22) | 3-year OS rate | NIL 300–400 mg | 92.31 | 39 | IM 400 mg | 79.49 | 39 | 1.16 (0.97–1.40) | |
Jabbour, 2014 (19) | 3-year OS rate | DAS 100 mg | 93.82 | 259 | IM 400 mg | 93.08 | 260 | 1.01 (0.96–1.05) | |
Kantarjian, 2012 (20) | 2-year OS rate | DAS 100 mg | 95.37 | 259 | IM 400 mg | 95.38 | 260 | 1.00 (0.97–1.03)a | |
Cortes, 2020 (25) | 2-year OS rate | DAS 100 mg | 97.70 | 174 | IM 400 mg | 96.51 | 86 |
a, RR reflects the pooled effect size through the meta-analysis. PFS, progression-free survival; OS, overall survival; RR, risk ratios; IM, imatinib; DAS, dasatinib; NIL, nilotinib; BOS, bosutinib.