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Purinergic signaling in OB in EAE. Schematic summary of the present study. The blue markers show the purinome components whose expression and cellular localization have changed significantly. Infiltrated macrophages and ameboid microglia overexpress A3R, while the latter also upregulates the expression of eN/CD73, A2BR, and P2X4R. Adenosine receptor A1R increased in mitral and tufted cells, likely influencing resting network activity in OB.
