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. 2024 Jul 30;18:1407975. doi: 10.3389/fncel.2024.1407975

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Copyright © 2024 Stekic, Dragic, Stanojevic, Zaric Kontic, Stevanovic, Zeljkovic Jovanovic, Mihajlovic and Nedeljkovic.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD4-directed immunohistochemical labeling of the olfactory bulb. (A–C) In control sections, CD4⁺ cells were not seen within OB tissue; only a few CD4⁺ T cells were restricted to the meningeal surface (arrows). (D,E) In EAE sections, numerous CD4⁺ T cells infiltrated the ONL from the meningeal side and reached the GL and EPL. (F) CD4⁺ cells around the blood vessels. Scale bar: (A,D) 1,000 μm; (B,E) 200 μm; (C,F) 100 μm. GCL, granule cell layer; GL, glomerular layer; EPL, external plexiform layer; MCL, mitral cell layer; ONL, olfactory nerve layer.