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. 2024 Jul 30;18:1407975. doi: 10.3389/fncel.2024.1407975

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Copyright © 2024 Stekic, Dragic, Stanojevic, Zaric Kontic, Stevanovic, Zeljkovic Jovanovic, Mihajlovic and Nedeljkovic.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GFAP-directed immunohistochemical labeling of the olfactory bulb. (A) The pattern of GFAP-ir in the control section at low magnification. (B) GFAP-ir mainly marks astrocytes in the ONL, GL (magnified in B′), and (C) RMS. (D,E) GFAP-ir in the EAE section shows slightly hypertrophied astrocytes in (F) ONL, (G) GL, and (H) EPL with non-overlapping distribution, and a less intense GFAP-ir in the RMS. GCL, granule cell layer; GL, glomerular layer; EPL, external plexiform layer; IPL, internal plexiform layer; MCL, mitral cell layer; ONL, olfactory nerve layer; RMS—rostral migratory stream; V—tip of the lateral ventricle. Scale bar: 500 μm in (A,D); 200 μm in (B,C,E) and 50 μm in (B′,F–I).