Table 3.

Cox proportional hazards regression.

		Univariable			Multivariable
n = 71	N	HR	95 % C.I.	p-value	HR	95 % C.I.	p-value
Age at Diagnosis	71	1.06	(1.03–1.09)	<0.001	1.11	(1.04–1.17)	0.001
Sex
Male	38	ref	–	–	ref	–	–
Female	33	0.44	(0.19–1.01)	0.051	0.31	(0.07–1.27)	0.102
Race
White	59	ref		–
African-American	8	0.23	(0.03–1.71)	0.152
Other/Unknown	4	1.29	(0.30–5.52)	0.729
Charlson-Deyo Score
0	57	ref	–	–
1	11	0.62	(0.19–2.08)	0.442
≥2	3	1.05	(0.14–7.90)	0.963
Lymphovascular Invasion
Absent	19	ref	–	–	Excluded from MVA due to missing values
Present	14	4.88	(1.24–19.24)	0.023
Unknown	12	0.97	(0.16–5.83)	0.974
Tumor Size (mm), (median, IQR)	62	1.02	(1.00–1.05)	0.040	0.98	(0.92–1.04)	0.495
Number of Positive Lymph Nodes	51	1.19	(1.09–1.30)	<0.001	1.19	(1.02–1.38)	0.025
Tumor Location
Distal Bile Duct	20	ref	–	–
Proximal Bile Duct/Perihilar	10	1.50	(0.42–5.33)	0.528
Cystic Duct	12	0.48	(0.10–2.38)	0.369
Other NOS	29	1.44	(0.55–3.79)	0.463
Histology
Neuroendocrine Tumor	62	ref	–	–	ref	–	–
Small/Large Cell Tumor	9	4.76	(1.97–11.47)	0.001	1.32	(0.35–4.97)	0.683
Tumor Morphology
Well Differentiated	39	ref	–	–	ref	–	–
Moderately Differentiated	9	4.52	(1.07–19.10)	0.040	38.84	(4.11–366.99)	0.001
Poorly Differentiated/Undifferentiated	23	15.58	(5.66–42.91)	<0.001	22.30	(3.78–131.49)	0.001
Chemotherapy
No	53	ref	–	–	ref	–	–
Yes	12	2.66	(1.14–6.17)	0.023	0.32	(0.05–2.13)	0.236
Unknown	6	0.67	(0.09–5.04)	0.696	1.69	(0.16–17.60)	0.661
Radiation
No	63	ref	–	–
Yes	8	2.27	(0.85–6.02)	0.101