Table 2. Baseline PFTs, radiology, and echocardiography.
| Characteristic | ILD exacerbation post-procedure (n=4) | Patients without ILD exacerbation (n=107) | Total (n=111) |
|---|---|---|---|
| FEV1, %, median (IQR) | 81.5 (18.0) | 76.5 (23.0) | 77 (23.8) |
| FVC, %, median (IQR) | 78.0 (22.5) | 74.5 (25.3) | 74.5 (24.0) |
| FEV1/FVC ratio, median (IQR) | 90.0 (83.4) | 85.0 (76.0) | 85.0 (76.0) |
| TLC, %, median (IQR) | 73.0 (15.5) | 68.0 (22.3) | 68.0 (20.5) |
| DLCO, mL/min/mmHg, median (IQR) | 54.7 (28.1) | 50.5 (22.5) | 51.0 (22.5) |
| 6MWT distance, meters, median (IQR) | 381.0 (0.0) | 330.0 (156.2) | 331.5 (149.9) |
| CT findings, n (%) | |||
| Traction bronchiectasis | 2 (50.0) | 53 (49.5) | 55 (49.5) |
| Bronchiolectasis | 1 (25.0) | 21 (19.6) | 22 (19.8) |
| Honeycombing | 2 (50.0) | 23 (21.5) | 25 (22.5) |
| Ground-glass opacities | 2 (50.0) | 53 (49.5) | 55 (49.5) |
| Reticulations | 2 (50.0) | 60 (56.1) | 62 (55.9) |
| Interlobular septal thickening, n (%) | 1 (25.0) | 24 (22.4) | 25 (22.5) |
| Emphysema | 0 | 19 (17.8) | 19 (17.1) |
| Bullae | 0 | 4 (3.7) | 4 (3.6) |
| Cysts | 1 (25.0) | 13 (12.1) | 14 (12.6) |
| Nodules | 1 (25.0) | 23 (21.5) | 24 (21.6) |
| Tree-in-bud | 0 | 5 (4.7) | 5 (4.5) |
| Upper lobe predominant disease | 1 (25.0) | 29 (27.1) | 30 (27.0) |
| Lower lobe predominant disease | 1 (25.0) | 39 (36.4) | 40 (36.0) |
| Diffuse disease | 1 (25.0) | 37 (34.6) | 38 (34.2) |
| TTE findings | |||
| LVEF, %, median (IQR) | 57.5 (8.8) | 60.0 (5.0) | 60.0 (54.0) |
| RVSP, mmHg, median (IQR) | 45.0 (0.0) | 32.0 (18.0) | 33.5 (30.1) |
| Tricuspid regurgitant peak velocity, m/s, median (IQR) | 2.6 (1.5) | 2.4 (0.8) | 2.4 (2.1) |
| Aortic stenosis present, n (%) | 0 | 5 (4.7) | 5 (4.5) |
| Aortic regurgitation present, n (%) | 0 | 22 (20.6) | 22 (19.8) |
| Mitral stenosis present, n (%) | 0 | 2 (1.9) | 2 (1.8) |
| Mitral regurgitation present, n (%) | 2 (50.0) | 47 (43.9) | 49 (44.1) |
| Tricuspid regurgitation present, n (%) | 4 (100.0) | 58 (54.2) | 62 (55.9) |
| Pre-procedure BAL, median (IQR) | |||
| Polys, % | 46.0 (74.3) | 25.0 (45.0) | 25.0 (45.0) |
| Lymphs, % | 9.0 (48.3) | 5.0 (11.5) | 5.0 (12.0) |
| Eosinophils, % | 5.5 (7.0) | 2.0 (5.0) | 2.0 (5.0) |
| Monocytes, % | 2.0 (67.0) | 33.0 (60.3) | 33.0 (62.5) |
| Macrophages, % | 23.0 (0.0) | 67.0 (55.0) | 67.0 (59.3) |
PFT, pulmonary function test; ILD, interstitial lung disease; FEV1, forced expiratory volume in one second; IQR, interquartile range; FVC, forced vital capacity; TLC, total lung capacity; DLCO, diffusion capacity of carbon monoxide; 6MWT, 6-minute walk test; CT, computed tomography; TTE, transthoracic echocardiogram; LVEF, left ventricular ejection fraction; RVSP, right ventricular systolic pressure; BAL, bronchoalveolar lavage.