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. 2024 Jul 9;10(15):e34321. doi: 10.1016/j.heliyon.2024.e34321

Fig. 7.

Fig. 7

The anti-skin photoaging function of hADSC exosomal SFN via a NF-κB signaling pathway is regulated by SIRT1. a and b Representative WB image of SIRT1, p-p65, p65 and IL-6 in each group (a). Quantitative analysis (b). c and d Representative WB image of SIRT1 after SFN overexpressed in HaCaT cells. Full-length blots/gels are presented in Supplementary original image of the blotting. WB Quantitative analysis and IL-6 quantification was performed by qPCR (d). e Schematic illustration of the role of hADSC-Exo and VE on protecting skin photoaging. n = 3. Control, non-exposed HaCaT cells. UV, UVB-exposed HaCaT cells. UV + VE, VE-pretreated UVB-exposed HaCaT cells. UV + EXO, hADSC-Exo-pretreated UVB-exposed HaCaT cells. UV + VE + EXO, hADSC-Exo and VE-pretreated UVB-exposed HaCaT cells. Differences in five groups were assessed by Tukey's multiple comparison test one-way ANOVA, error bars represent S.E.M. Compared with control group, markered with *p < 0.05, **p < 0.01, ***p < 0.001. Compared with UV group, markered with #p < 0.05,##p < 0.01,###p < 0.001,####p < 0.0001.