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. 2024 Jul 26;14(8):5358–5372. doi: 10.21037/qims-23-1614

Table 3. Clinical and radiological relevant data of the patients.

Characteristic Total (n=175) PNI positive (n=78) PNI negative (n=97) P value
Age (years), mean ± SD 63.89±10.14 63.87±9.59 63.91±10.60 0.864
Sex, n (%) 0.289
   Male 116 (66.3) 55 (70.5) 61 (62.9)
   Female 59 (33.7) 23 (29.5) 36 (37.1)
CEA level, n (%) 0.056
   <5 ng/mL 127 (72.6) 51 (65.4) 76 (78.4)
   ≥5 ng/mL 48 (27.4) 27 (34.6) 21 (21.6)
CA199 level, n (%) 0.647
   <37 U/mL 159 (90.9) 70 (89.7) 89 (91.8)
   ≥37 U/mL 16 (9.1) 8 (10.3) 8 (8.2)
Tumor location, n (%) 0.884
   Lower 48 (27.4) 20 (25.6) 28 (28.9)
   Middle 74 (42.3) 35 (44.9) 39 (40.2)
   Upper 53 (30.3) 23 (29.5) 30 (30.9)
MRI T stage, n (%) 0.266
   T1–2 64 (36.6) 25 (32.1) 39 (40.2)
   T3–4 111 (63.4) 53 (67.9) 58 (59.8)
MRI N status, n (%) 0.813
   N0 87 (49.7) 38 (48.7) 49 (50.5)
   N1–2 88 (50.3) 40 (51.3) 48 (49.5)
mrEMVI, n (%) 0.274
   Negative 124 (70.9) 52 (66.7) 72 (74.2)
   Positive 51 (29.1) 26 (33.3) 25 (25.8)
mrMRF, n (%) 0.572
   Negative 164 (93.7) 74 (94.9) 90 (92.8)
   Positive 11 (6.3) 4 (5.1) 7 (7.2)
PCI, n (%) 0.0002*
   <1/4 0 (0) 0 (0) 0 (0)
   1/4≤–≤1/2 105 (60.0) 36 (46.2) 69 (71.1)
   1/2<–≤3/4 63 (36.0) 39 (50.0) 24 (24.8)
   >3/4 7 (4.0) 3 (3.8) 4 (4.1)

*, P<0.05. PNI, perineural invasion; SD, standard deviation; CEA, carcinoembryonic antigen; CA199, carbohydrate antigen 199; MRI, magnetic resonance imaging; mrEMVI, MRI-extramural venous invasion; mrMRF, MRI-reported mesorectal fascia; PCI, percentage of rectal wall circumference invaded.