Table 5. Univariable and multivariable analysis of potential independent predictors of the composite primary endpoint.
| Variable | p-value univariable | p-value multivariable |
OR 95% CI |
|---|---|---|---|
| Age, years | <0.001 | 0.013 | 0.03 (0.01 to 0.06) |
| Sex | 0.982 | ||
| Hypertension | 0.080 | ||
| Dyslipidaemia | 0.256 | ||
| Diabetes | 0.932 | ||
| Smoking | 0.037 | 0.207 | |
| AF type | 0.253 | ||
| Previous ischaemic stroke | <0.001 | 0.022 |
–0.61 (–1.14 to –0.09) |
| Previous heart failure | <0.001 | <0.001 | 0.77 (0.38 to 1.16) |
| Previous peripheral artery disease | 0.274 | ||
| Previous coronary artery disease | 0.382 | ||
| Previous LV dysfunction (<40%) | 0.548 | ||
| CHA2DS2-VASc | 0.192 | ||
| HAS-BLED | 0.052 | ||
| eGFR, mL/min/1.73 m2 | <0.001 | 0.060 | |
| Prior dialysis | 0.061 | ||
| Previous cirrhosis | 0.613 | ||
| Previous recent major surgery | 0.131 | ||
| Prior major bleeding | 0.009 | 0.021 | 0.86 (0.13 to 1.60) |
| Previous intracranial bleeding | <0.001 | 0.004 |
–1.00 (–1.68 to –0.31) |
| Previous gastrointestinal bleeding | <0.001 | 0.246 | |
| Previous spontaneous haematoma | 0.390 | ||
| Previous intravitreal bleeding | 0.748 | ||
| Prior labile INR | 0.026 | 0.123 | |
| LAAO indication | 0.414 | ||
| P-values in bold represent statistical significance. AF: atrial fibrillation; CI: confidence interval; eGFR: estimated glomerular filtration rate; INR: international normalised ratio; LAAO: left atrial appendage occlusion; LV: left ventricular; OR: odds ratio | |||