FIG. 6.
Survival rates of mice immunized with gD DNA vaccines plus chemokine cDNAs after a high-lethal-dose challenge. Each group of mice (n = 8) was immunized with gD DNA vaccines (60 μg per mouse) plus α-chemokine (A) or β-chemokine (B) cDNAs (40 μg per mouse) at 0 and 2 weeks. Three weeks after the second immunization, the mice were challenged i.vag. with 200 LD50 of HSV-2 strain 186 (7 × 105 PFU). Asterisks indicate results that are statistically significant at a P value of <0.05 using ANOVA compared to those for mice coinjected with IP-10 or MCP-1.