Figure 2.

Association analysis for individual variants

The p values (y axis, negative log10) obtained in the association analysis of 1,211 non-singleton variants from the POP_all analysis. Variants are grouped according to the genes (x axis, sorted alphabetically) in which they are located. Results for case-control definitions other than POP_all are provided in Figure S3. Dotted line: Lenient significance threshold, correcting for the number of variants tested (α = 4.1 × 10⁻⁵). Dashed line: Strict significance threshold, also taking into account multiple testing due to additional case-control definitions (α = 6.7 × 10⁻⁶). Variants with p values below the lenient significance threshold are marked in green and were only found in genes selected based on prior GWAS evidence, i.e., FYCO1 and XCR1 at 3p21.31, IFNAR2 at 21q22.11.