Figure 10.

Antitumor growth activity in a CCNE amplified (CN = 12) gastric PDX model CRT00292. NOG mice were inoculated subcutaneously with tumor fragments and randomized (n = 7/group) when tumors reached an average of 150–200 mm³. Animals were dosed daily with XC219 43 (30 and 100 mpk × 14d, i.p.). In the highest dose group 3 animals were moribund or withdrawn from treatment. One-way ANOVA, Dunnett’s multiple comparison test was performed reporting statistical significance of 100 mpk group, p value = 0.0079.