Table 1.
Descriptive Statistics
| Pre–Shortage Period |
Shortage Period |
|||||
|---|---|---|---|---|---|---|
| Shortage and Change | No. of Hospitals | Pooled | Median (1st, 3rd Quartiles) | Pooled | Median (1st, 3rd Quartiles) | P Value (Wilcoxon) |
|
| ||||||
| PIP/TAZO use (DOT/1000 DAR) | ||||||
| Mild shortage (≤33% reduction) | 39 | 72.1 | 68.0 (53.9, 86.1) | 63.3 | 58.4 (50.4, 78.3) | .0809 |
| Moderate shortage (34%–66% reduction) | 20 | 83.5 | 89.1 (674, 104.3) | 41.6 | 43.8 (33.8, 54.1) | <.0001 |
| Severe shortage (>66% reduction) | 29 | 79.1 | 80.8 (676, 100.7) | 11.9 | 8.1 (1.9, 19.3) | <.0001 |
| Moderate/severe combined | 49 | 80.8 | 81.4 (676, 100.7) | 23.6 | 19.6 (3.4, 38.7) | <.0001 |
| High-risk antibiotic use change (DOT/1000 DAR) | ||||||
| No increase (≤ 0%) | 16 | 237.0 | 239.5 (216.7, 294.7) | 224.8 | 222.3 (199.6, 273.3) | .2911 |
| Minor increase (1%–10%) | 21 | 239.0 | 274.1 (218.0, 303.2) | 250.9 | 289.7 (230.0, 321.0) | .0061 |
| Intermediate increase (11%–30%) | 35 | 271.2 | 2876 (222.0, 329.2) | 321.0 | 341.1 (268.4, 396.0) | <.0001 |
| Large increase (>30%) | 16 | 224.4 | 215.6 (1872, 291.2) | 309.0 | 319.1 (259.4, 3872) | <.0001 |
| All 3 increasing groups combined | 72 | 253.2 | 270.2 (212.2, 313.5) | 301.5 | 308.2 (252.1,385.4) | <.0001 |
Abbreviations: DAR, days at risk; DOT, days of therapy; PIP/TAZO, piperacillin/tazobactam.