Table 2. Allometric Scaling to Predict Human Clearance.

allometric scaling equation	allometric scaling method	notes	reference
	Single species scaling	BW is the body weight, b is the allometry exponent. Value of the allometry exponent is 0.60, 0.65, 0.70, 0.75, 0.80, 0.85, or 0.9033	(33, 34)
	Single species scaling	BW is the body weight	(35)
	One- or two-species scaling by Tang method	arat-dog is the coefficient for rat-dog method; arat-monkey is the coefficient for rat-monkey method	(36)
	Single species scaling using hepatic blood flow	HBF is the hepatic blood flow	(35)
	Scaling using liver blood flow	LBF is the liver blood flow, the value of LBF (mL/min/kg) should be multiplied by the corresponding body weight of the species	(33, 36)
	Multiple species scaling by simple allometry (SA)	BW is the body weight, a is the coefficient, and b is the allometry exponent	(33, 34)
	Multiple species scaling by exponent rule-corrected allometry (ROE)	MLP is the maximum life-span potential and BRW is the brain weight of the organism, BW is the body weight, a is the coefficient, and b is the allometry exponent	(33, 34)
		If b < 0.71 in simple allometry, no correction factor is applied; if 0.71 ≤ b < 1, MLP is used as a correction factor; if 1 ≤ b, BRW is used as an correction factor33 If 0.56 < b < 0.70, simple allometry is used, 0.71 < b < 0.99 or 1.0 ≤ b ≤ 1.3 MLP or BRW is used for small molecules34
	Product of MLP and Clearance (MLP × Clearance)	MLP is the maximum life-span potential and BW is the body weight, a is the coefficient, b is the allometry exponent, 93.4 is the human MLP in years, and this relation is predicted for the human clearance of Antibody–drug conjugates (ADCs)	(34)
	Product of Brain Weight and Clearance (BRW × Clearance)	BRW is the brain weight, BW is the body weight, a is the coefficient, b is the allometry exponent, 1400 is the human brain weight in grams, and this relation is predicted for the human clearance of Antibody–drug conjugates (ADCs)	(34)
	Multiple species scaling by multiexponential allometry (MA)	BW is the body weight, a is the coefficient and b is the allometry exponent determined from the simple allometry analysis.	(33)
	Multiple species scaling by exponent rule-corrected multiexponential allometry (SA+MA)	BW is the body weight, a is the coefficient and b is the allometry exponent. If b < 0.71, simple allometry method is applied with no correction factor; if b ≥ 0.71, the multiexponential allometry equation is used.	(33)
	Single species scaling using different physiological parameters	LW is the liver weight, KW is the kidney weight, LBF is the liver blood flow, KBF is the kidney blood flow, and LFR is the lymph flow rate	(37)