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. 2024 Jul 12;7(8):2251–2279. doi: 10.1021/acsptsci.4c00250

Table 3. Human Equivalent Dose (HED) Prediction Methods.

HED prediction equation HED prediction method notes reference
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Dose prediction by linear method based on clearance values Dose and clearance values are in absolute numbers, not normalized to body weight (37)
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Dose prediction by exponential method based on clearance values Dose and clearance values are in absolute numbers, not normalized to body weight (37)
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Dose prediction based on body weight Dose values are normalized to body weight (3739)
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Dose prediction based on predicted human clearance Dose values are normalized to body weight (37)
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Dose prediction based on correction factor Kf is the correction factor; dose values are normalized to body weight (3840)