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Differential effects of sialic acid residues linked α2-3, α2-6, or α2-8 on viral infectivity. SIVmac239 was treated with the indicated neuraminidases as described in Materials and Methods. The treated virus was then used to infect CEM×174 SIV-SEAP cells, and the amount of SEAP activity was quantitated at approximately 60 h postinfection. The standard deviation for each experiment is indicated.
