Table 2.
Dynamic contrast enhanced CT parameters associated with patient outcome by log rank tests on baseline, day seven and day thirty of follow-up
| Perfusion Parameter | Optimal cut-off OS | Range | Median Os, mo | Log-Rank (P) | Optimal cut-off PFS | Range | Median PFS, mo | Log-Rank (P) |
|---|---|---|---|---|---|---|---|---|
| Baseline (n = 32) | ||||||||
| Blood Volume | ≤ 12.97 (n = 10) | 5.34 to 11.77 | 7.87 | 0.050 | ≤ 12.97 (n = 10) | 5.34 to 11.77 | 2.48 | 0.046 |
| > 12.97 (n = 22) | 12.97 to 120.46 | 26.37 | > 12.97 (n = 22) | 12.97 to 120.46 | 14.58 | |||
| Blood Flow (Deconvolution) | ≤ 75.02 (n = 6) | 43.93 to 75.02 | 25.4 | 0.11 | ≤ 75.02 (n = 6) | 43.93 to 75.02 | 2.45 | 0.09 |
| > 75.02 (n = 26) | 79.23 to 1314.05 | 6.78 | > 75.02 (n = 26) | 79.23 to 1314.05 | 9.92 | |||
| Blood Flow (Max slope) | ≤ 302.94 (n = 24) | 112.04 to 302.94 | 25.4 | 0.21 | ≤ 302.94 (n = 24) | 112.04 to 302.94 | 5.57 | 0.29 |
| > 302.94 (n = 8) | 579.03 to 2465.04 | 21.5 | > 302.94 (n = 8) | 579.03 to 2465.04 | 20 | |||
| Permeability | ≤ 28.78 (n = 17) | 6.19 to 28.78 | 14.32 | 0.11 | ≤ 31.29 (n = 20) | 6.19 to 31.29 | 3.75 | 0.27 |
| > 28.78 (n = 15) | 29.44 to 63.29 | 26.23 | > 31.29 (n = 12) | 34.75 to 63.29 | 15.43 | |||
| Relative change from baseline to day 7 (n = 23) | ||||||||
| Blood Volume | ≤ 7.31 (n = 15) | -64.39 to 7.31% | 24.6 | 0.2 | ≤ 5.61 (n = 14) | -64.39 to 5.61% | 5.73 | 0.35 |
| > 7.31 (n = 8) | 8.81 to 61.49% | 10.97 | > 5.61 (n = 9) | 7.31 to 61.49% | 2.87 | |||
| Blood Flow (Deconvolution) | ≤ 24.50 (n = 20) | -72.81 to 24.50% | 23.12 | 0.025 | ≤ 12.04 (n = 17) | -72.80 to 12.04% | 13.73 | 0.018 |
| > 24.50 (n = 3) | 39.24 to 69.05% | 8.73 | > 12.04 (n = 6) | 15.92 to 69.05% | 2.47 | |||
| Blood Flow (Max slope) | ≤ -43.58 (n = 19) | -76.01 to -43.58% | 27.72 | 0.16 | ≤ -43.58 (n = 19) | -76.01 to -43.58% | 20 | 0.16 |
| > -43.58 (n = 4) | -35.72 to 143.49% | 18.83 | > -43.58 (n = 4) | -35.72 to 143.49% | 4.87 | |||
| Permeability | ≤ -0.25 (n = 7) | -41.69 to -0.25% | 15.43 | 0.31 | ≤ 48.82 (n = 19) | -41.69 to 48.82% | 5.57 | 0.22 |
| > -0.25 (n = 13) | 0.52 to 107.17% | 21.67 | > 48.82 (n = 3) | 58.81 to 107.17% | 29.23 | |||
| Relative change from baseline to day 30 (n = 22) | ||||||||
| Blood Volume | ≤ 7.67 (n = 10) | -90.09 to 7.67% | 18.5 | 0.69 | ≤ -7.60 (n = 13) | -90.09 to -7.60% | 4.2 | 0.33 |
| > 7.67 (n = 12) | 10.35 to 103.96% | 21.7 | > -7.60 (n = 9) | 7.67 to 103.96% | 6.1 | |||
| Blood Flow (Deconvolution) | ≤ 12.96 (n = 9) | -79.27 to 12.96% | 15.43 | 0.14 | ≤ 4.07 (n = 9) | -79.27 to 4.07% | 4.2 | 0.12 |
| > 12.96 (n = 12) | 13.40 to 47.11% | 25.53 | > 4.07 (n = 12) | 12.96 to 47.11% | 8.47 | |||
| Blood Flow (Max slope) | ≤ 8.98 (n = 14) | -94.79 to 8.98% | 14.32 | 0.064 | ≤ 24.59 (n = 17) | -94.79 to 24.59% | 5.57 | 0.55 |
| > 8.98 (n = 7) | 18.10 to 49.11% | 29.17 | > 24.59 (n = 4) | 25.10 to 49.11% | 14.83 | |||
| Permeability | ≤ -1.11 (n = 7) | -65.41 to -1.11% | 29.17 | 0.13 | ≤ 8.66 (n = 12) | -65.41 to 8.66% | 5.95 | 0.23 |
| > -1.11 (n = 13) | -0.40 to 1166.83% | 18.83 | > 8.66 (n = 8) | 19.40 to 1166.83% | 3.15 | |||
OS Overall Survival, PFS Progression Free Survival