Table 3.
Univariate cox regression for the effect of dynamic contrast enhanced CT (DCE-CT) parameters at baseline and day seven of follow-up on patient outcome
| Perfusion Parameter | Hazard Ratio (95% CI) OS | P | Hazard Ratio (95% CI) PFS | P |
|---|---|---|---|---|
| Baseline | ||||
| Blood Volume | 0.99 (0.97 to 1.01) | 0.300 | 0.99 (0.98 to 1.01) | 0.592 |
| Blood Volume Categorical | 2.48 (0.97 to 6.34) | 0.057 | 2.44 (0.99 to 6.02) | 0.053 |
| Blood Flow (Deconvolution) | 0.99 (0.99 to 1.00) | 0.210 | 0.99 (0.99 to 1.00) | 0.485 |
| Blood Flow (Deconvolution) Categorical | 2.28 (0.97 to 6.34) | 0.121 | 2.38 (0.86 to 6.62) | 0.095 |
| Blood Flow (Max-slope) | 0.99 (0.99 to 1.00) | 0.229 | 0.99 (0.99 to 1.00) | 0.382 |
| Blood Flow (Max-slope) Categorical | 2.15 (0.62 to 7.39) | 0.226 | 1.71 (0.63 to 4.66) | 0.294 |
| Permeability | 1.00 (0.97 to 1.04) | 0.876 | 1.00 (0.97 to 1.04) | 0.628 |
| Permeability Categorical | 0.47 (0.18 to 1.21) | 0.117 | 0.79 (0.33 to 1.89) | 0.602 |
| Relative change from baseline to day 7 | ||||
| Blood Volume | 1.00 (0.98 to 1.01) | 0.940 | 1.00 (0.98 to 1.01) | 0.708 |
| Blood Volume Categorical | 0.50 (0.17 to 1.48) | 0.212 | 0.62 (0.23 to 1.68) | 0.350 |
| Blood Flow (Deconvolution) | 1.00 (0.99 to 1.02) | 0.499 | 1.01 (0.99 to 1.02) | 0.484 |
| Blood Flow (Deconvolution) Categorical | 0.26 (0.06 to 0.93) | 0.039 | 0.27 (0.09 to 0.85) | 0.026 |
| Blood Flow (Max-slope) | 1.00 (0.99 to 1.02) | 0.367 | 1.00 (0.99 to 1.01) | 0.646 |
| Blood Flow (Max-slope) Categorical | 0.26 (0.03 to 1.96) | 0.190 | 0.36 (0.03 to 1.96) | 0.181 |
| Permeability | 0.99 (0.98 to 1.01) | 0.481 | 1.00 (0.98 to 1.01) | 0.640 |
| Permeability Categorical | 1.71 (0.59 to 4.95) | 0.320 | 3.35 (0.44 to 25.64) | 0.245 |