Table 4.

Multivariate Cox regression analysis for all patients (continuous variables) (n = 754).

Covariate		Multivariate analysis
		HR	95% CI	p value
BCA parameters
AFP	Continuous	1.0	1.0–1.1	0.347
Albumin	Continuous	0.6	0.5–0.7	<0.001
Bilirubin	Continuous	1.2	1.1–1.3	<0.001
AST level	Continuous	1.1	1.0–1.2	0.003
INR level	Continuous	1.0	0.9–1.1	0.524
Tumor number	Continuous	1.1	1.0–1.2	0.116
Max. lesion size	Continuous	1.3	1.1–1.5	<0.001
SM normalized∗	Continuous	0.9	0.8–1.0	0.039
TAT normalized∗	Continuous	1.0	1.0–1.0	0.424
SAT normalized∗	Continuous	1.0	1.0–1.0	0.349
BCA parameters/Bone
AFP	Continuous	1.0	1.0–1.1	0.306
Albumin	Continuous	0.6	0.5–0.7	<0.001
Bilirubin	Continuous	1.2	1.1–1.3	<0.001
AST level	Continuous	1.1	1.0–1.2	0.005
INR level	Continuous	1.0	0.9–1.1	0.686
Tumor number	Continuous	1.1	1.0–1.2	0.044
Max. lesion size	Continuous	1.3	1.1–1.5	<0.001
SM/Bone	Continuous	0.9	0.8–1.0	0.036
TAT/Bone	Continuous	1.0	0.9–1.1	0.985
Sarcopenia marker
AFP	Continuous	1.0	1.0–1.1	0.309
Albumin	Continuous	0.6	0.5–0.7	<0.001
Bilirubin	Continuous	1.2	1.1–1.3	<0.001
AST level	Continuous	1.1	1.0–1.2	0.006
INR level	Continuous	1.0	0.9–1.1	0.694
Tumor number	Continuous	1.1	1.0–1.2	0.044
Max. lesion size	Continuous	1.3	1.1–1.5	<0.001
Sarcopenia marker	Continuous	0.9	0.8–1.0	0.030

p values in bold show significant values.

AFP, alpha fetoprotein; ALT, alanine aminotransferase; AST, aspartate aminotransferase; IMAT, intermuscular adipose tissue; INR, international normalized ratio; SAT, subcutaneous adipose tissue; SM, skeletal muscle volume; TAT, total adipose tissue; VAT, visceral adipose tissue.

^∗Volumes normalized to the slice number of the abdominal cavity.