Table 5.
Univariate and multivariate Cox regression analysis for all patients (categorized variables) (N = 754).
| Covariate | Univariate analysis |
Multivariate analysis |
|||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | ||
| Age | ≥70 years | 0.9 | 0.8–1.1 | 0.230 | |||
| AFP | >400 ng/ml | 1.0 | 0.9–1.3 | 0.720 | |||
| Albumin | <35 g/L | 2.1 | 1.7–2.5 | <0.001 | 1.8 | 1.5–2.3 | <0.001 |
| Bilirubin | ≥1.2 mg/dl | 1.8 | 1.5–2.2 | <0.001 | 1.6 | 1.3–2.0 | <0.001 |
| AST level | >31 U/L | 1.4 | 1.0–1.9 | 0.054 | |||
| ALT level | ≥35 U/L | 1.1 | 0.9–1.3 | 0.430 | |||
| INR level | >1.2 | 0.7 | 0.6–0.9 | <0.001 | 1.1 | 0.8–1.3 | 0.665 |
| Platelet count | <150/nl | 1.1 | 0.9–1.3 | 0.500 | |||
| Tumor number | ≥2 | 1.4 | 1.1–1.7 | 0.001 | 1.2 | 1.0–1.5 | 0.048 |
| Max. lesion size | >5.0 cm | 1.6 | 1.3–2.0 | <0.001 | 1.6 | 1.3–2.0 | <0.001 |
| SM normalized∗ | <89.0 | 1.6 | 1.2–2.0 | <0.001 | 1.4 | 1.1–1.8 | 0.019 |
| TAT normalized∗ | <197.6 | 0.6 | 0.5–0.8 | <0.001 | 0.8 | 0.6–1.2 | 0.269 |
| IMAT normalized∗ | <18.8 | 0.8 | 0.7–1.0 | 0.052 | |||
| SAT normalized∗ | <119.5 | 0.7 | 0.5–0.8 | <0.001 | 1.0 | 0.7–1.3 | 0.774 |
| VAT normalized∗ | <58.2 | 0.8 | 0.7–1.0 | 0.030 | 1.1 | 0.9–1.4 | 0.497 |
p values in bold show significant values.
AFP, alpha fetoprotein; ALT, alanine aminotransferase; AST, aspartate aminotransferase; HR, hazard ratio; IMAT, intermuscular adipose tissue; INR, international normalized ratio; SAT, subcutaneous adipose tissue; SM, skeletal muscle volume; TAT, total adipose tissue; VAT, visceral adipose tissue.
∗
Volumes normalized to the slice number of the abdominal cavity.