Table 6.
Univariate and multivariate Cox regression analysis for patients within BCLC stage B (n = 388).
| Covariate | Univariate analysis |
Multivariate analysis |
|||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | ||
| Age | ≥70 years | 1.0 | 0.8–1.2 | 0.720 | |||
| AFP | >400 ng/ml | 1.1 | 0.9–1.5 | 0.370 | |||
| Albumin | <35 g/L | 1.9 | 1.5–2.4 | <0.001 | 1.7 | 1.3–2.2 | <0.001 |
| Bilirubin | ≥1.2 mg/dl | 1.8 | 1.4–2.2 | <0.001 | 1.5 | 1.1–2.0 | 0.005 |
| AST level | >31 U/L | 1.3 | 0.9–2.1 | 0.220 | |||
| ALT level | ≥35 U/L | 1.0 | 0.8–1.4 | 0.750 | |||
| INR level | >1.2 | 0.6 | 0.5–0.8 | <0.001 | 1.0 | 0.7–1.3 | 0.748 |
| Platelet count | <150/nl | 1.2 | 0.9–1.6 | 0.210 | |||
| Tumor number | ≥2 | 1.0 | 0.7–1.5 | 0.870 | |||
| Max. lesion size | >5.0 cm | 1.2 | 1.0–1.6 | 0.110 | |||
| SM normalized∗ | <89.0 | 1.4 | 1.0–2.1 | 0.041 | 1.6 | 1.1–2.3 | 0.012 |
| TAT normalized∗ | <197.6 | 0.6 | 0.4–0.8 | <0.001 | 0.8 | 0.5–1.2 | 0.287 |
| IMAT normalized∗ | <18.8 | 0.8 | 0.6–1.1 | 0.150 | |||
| SAT normalized∗ | <119.5 | 0.6 | 0.4–0.9 | 0.016 | 0.8 | 0.5–1.1 | 0.523 |
| VAT normalized∗ | <58.2 | 0.7 | 0.5–0.9 | 0.001 | 0.9 | 0.6–1.1 | 0.289 |
p values in bold show significant values.
AFP, alpha fetoprotein; ALT, alanine aminotransferase; AST, aspartate aminotransferase; HR, hazard ratio; IMAT, intermuscular adipose tissue; INR, international normalized ratio; SAT, subcutaneous adipose tissue; SM, skeletal muscle volume; TAT, total adipose tissue; VAT, visceral adipose tissue.
∗
Volumes normalized to the slice number of the abdominal cavity.