Fig. 3.

Relation between daily dose of PEN in mg/kg BW and measures of copper metabolism in patients with WD who were stable on PEN.

(A) Dose and NCC-SP (n = 69). (B) Dose and NCC-Ex (n = 71). (C) Dose and UCE (n = 76). PEN dose in mg/kg tended to be negatively correlated with NCC-SP (p = 0.053) and NCC-Ex (p = 0.004). PEN dose did not correlate with UCE. BW, body weight; NCC, non-ceruloplasmin-bound copper; NCC-Ex, exchangeable copper; NCC-Sp, NCC determined from total copper protein speciation assay; PEN, D-penicillamine; UCE, 24-hour urinary copper excretion; WD, Wilson disease.