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. 2024 Aug 12;16(1):2388801. doi: 10.1080/19490976.2024.2388801

Figure 1.

Figure 1.

P. gingivalis promotes colorectal tumorigenesis by modulating iNKT cell functions. A) frequency of tumor-infiltrating iNKT cells and B) tumor-associated neutrophils in CRC patients (n = 31) positive (Pgpos; n = 16) or negative (Pgneg; n = 15) for P. gingivalis in their mucosa-associated microbiota with representative dot plots. C) CXCL16 concentration from tissue lysates (200 µg of total protein). D) schematic representation of the AOM-DSS experimental plan. E) tumour endoscopic score, AUC and representative endoscopic pictures, F) number and G) volume of tumors from AOM-DSS treated C57BL/6 animals orally gavaged with PBS (AOMCTRL) or 109 CFUs of P. gingivalis (AOMPg). H) frequency of tumor-infiltrating iNKT cells in AOMCTRL and AOMPg C57BL/6 mice with representative plots. I) t-sne map of iNKT cells based on phenograph metaclustering analysis of AOMCTRL and AOMPg tumor samples. J) balloon plot of the scaled integrated mean fluorescent intensity (iMFI) of phenograph clusters generated in panel J. K-M) frequency of tumor-infiltrating K) GM-CSF+ L) IL17+ and M) IL10+ iNKT cells in AOMCTRL and AOMPg C57BL/6 mice with representative plots. Data (n = 10, AOMCTRL; n = 11, AOMPg) from two pooled independent experiments representative of at least three.