Figure 1.

Interaction steps, primary sequences, and structures of the biomimetic silica‐precipitating systems R5 and synSil‐1A₁. a) The sequence of peptide R5. The peptide is stripped of all PTMs. Only the primary sequence mimics the natural natSil‐1A₁ peptide. The structure corresponds to the average side‐chain protonation state at the experimental pH of 6.5. b) The synthetic variant synSil‐1A_1, which lacks the RRIL motif of R5 but bears all naturally occurring PTMs, albeit somewhat shorter lysine LCPA modifications. c,d) Simplified visualization of major steps of the herein‐studied silicification processes.