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. 2024 Aug 12;9(5):e1168. doi: 10.1097/PR9.0000000000001168

Figure 2.

Figure 2.

von Frey hair threshold (mean ± SEM) in the male mice receiving intraplantar formalin (Fig. 1) assessed immediately before drug treatment at TX-1(red dashed vertical line: A). IP saline, IP vehicle, IP APAPa (ampoule) (100 mg/kg) or IP APAPp (powder) (100 mg/kg) or (B) IP saline, IP vehicle, IP APAPa (ampoule) (300 mg/kg) or IP APAPp (powder) (300 mg/kg) and formalin on day 1 (formalin) at +30 minutes (indicated by the vertical dotted black line) and after intraplantar formalin (+60 minutes). On day 12, von Frey thresholds were assessed at T = 0 and the animal then administered the same treatment as on day 1 (Tx-2) and then tested at intervals out to 240 minutes. At 1 hour after formalin flinching and then again at 7 and 9 days. Two-way repeated-measures ANOVA were performed with main effects Time and Time × Treatment showing significant (P < 0.01). Post hoc comparisons between treatments were made with Sidak. * (P < 0.05): Day 1 vs Pre Tx1 and Day 12 vs Pre Tx2. APAP, acetaminophen; IP, intraperitoneal.