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. 2024 Aug 12;9(5):e1168. doi: 10.1097/PR9.0000000000001168

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Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 4. — Tactile threshold (mean ± SEM) in male mice measured over time before (baseline: BL) and after unilateral hind paw incision on day 1 (vertical yellow bar) for the (A) ipsilateral and (B) contralateral hind paw in male mice. After 24 hours, on day 2 (Tx-1) again on day 8 (Tx-8), mouse received IP vehicle or acetaminophen (APAP: 300 mg/kg) at vertical dotted line. Two-way repeated-measures ANOVA. Time–treatment main effects were statistically significant (P < 0.0001). Post hoc comparisons vs respective presurgical baseline. P < 0.05. Post hoc comparisons (Sidak) vs respective Pre Tx 1 and Tx2 baselines (BL) *P < 0.05; **P < 0.01; ***P < 0.001. APAP, acetaminophen; IP, intraperitoneal.