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Gain-of-function studies. The efficiency of particle release by M domain mutants with pairs of acidic residue substitutions was determined as in Fig. 3. The acidic substitution mutants contained either no other changes or neutralizations of the first and third basic amino acids in the M domain (1,3 mutants). (A) Effects of acidic-to-basic residue changes; (B) effects of acidic-to-neutral residue changes.
