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. 2024 Aug 13;24(1):191. doi: 10.1007/s10238-024-01451-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Differential expression and prognostic value of Bud31 in various malignancies. A Expression profile of Bud31 across multiple cancer types, depicted as box plots. Data are segregated into normal (blue) and tumor (red) groups for each study identifier. B Violin plots illustrating the distribution of Bud31 expression in normal versus tumor samples from three independent datasets, with p-values indicating statistical significance. C Comparative immunohistochemical analysis of Bud31 protein levels in normal (left) and neoplastic (right) tissue sections. D Heatmap correlation matrix of Bud31 expression levels across different cancer subtypes, with intensity gradients representing expression magnitude. E Kaplan–Meier survival plots evaluating the correlation between Bud31 expression and overall survival in six distinct cancer cohorts, stratified by high (red) and low (blue) expression levels, accompanied by p-values and hazard ratios. * P < 0.05, **P < 0.01, ***P < 0.001