Table 1.
CHEC-SC participant demographics by CFTR modulator treatment at enrollment.
| Modulator at CHEC-SC Enrollment |
||||
|---|---|---|---|---|
| IVA (N=536) | LUM/IVA (N=785) | TEZ/IVA (N=697) | ELE/TEZ/IVA (N=1769) | |
|
| ||||
| Female Sex, n (%) | 273 (50.9%) | 368 (46.9%) | 364 (52.2%) | 849 (48.0%) |
| Age at sweat collection (years) | ||||
| Mean (SD) | 18.8 (15.4) | 16.7 (9.9) | 21.7 (10.6) | 23.4 (12.4) |
| Category, n (%) | ||||
| 0–1 years | 11 (2.1%) | 0 (0%) | 0 (0%) | 0 (0%) |
| 2–5 years | 82 (15.3%) | 91 (11.6%) | 0 (0%) | 0 (0%) |
| 6–11 years | 127 (23.7%) | 190 (24.2%) | 65 (9.3%) | 200 (11.3%) |
| 12–17 years | 108 (20.1%) | 218 (27.8%) | 251 (36.0%) | 547 (30.9%) |
| 18–25 years | 96 (17.9%) | 159 (20.3%) | 219 (31.4%) | 460 (26.0%) |
| >=26 years | 112 (20.9%) | 127 (16.2%) | 162 (23.2%) | 562 (31.8%) |
| Race, n (%) | ||||
| White | 511 (95.3%) | 763 (97.2%) | 675 (96.8%) | 1695 (95.8%) |
| Black or African American | 8 (1.5%) | 5 (0.6%) | 3 (0.4%) | 22 (1.2%) |
| Asian | 1 (0.2%) | 3 (0.4%) | 2 (0.3%) | 3 (0.2%) |
| American Indian or Alaska Native | 1 (0.2%) | 0 (0%) | 0 (0%) | 2 (0.1%) |
| Native Hawaiian or Other Pacific Islander | 0 (0%) | 1 (0.1%) | 1 (0.1%) | 1 (0.1%) |
| More than One Race | 5 (0.9%) | 1 (0.9%) | 10 (1.4%) | 25 (1.4%) |
| Unknown or Not Reported | 10 (1.9%) | 6 (0.8%) | 6 (0.9%) | 21 (1.2%) |
| Ethnicity, n (%) | ||||
| Hispanic or Latino | 60 (11.2%) | 32 (4.1%) | 28 (4.0%) | 100 (5.7%) |
| Not Hispanic or Latino | 476 (88.8%) | 752 (95.8%) | 668 (95.8%) | 1669 (94.3%) |
| Not Reported/Unknown | 0 (0%) | 1 (0.1%) | 1 (0.1%) | 0 (0%) |
| Diagnostic sweat chloride | ||||
| Mean (SD) | 84.0 (26.7) | 101.7 (12.8) | 98.8 (17.1) | 98.8 (18.4) |
| Median (Min, Max) | 91.0 (19.0, 176.0) | 101.5 (43.0, 165.0) | 100.3 (33.0, 165.0) | 101.0 (17.2, 165.0) |
| Category, n (%) | ||||
| 110+ mmol/L | 74 (13.8%) | 152 (19.4%) | 139 (19.9%) | 374 (21.1%) |
| 100 to <110 mmol/L | 90 (16.8%) | 241 (30.7%) | 178 (25.5%) | 466 (26.3%) |
| 80 to <100 mmol/L | 145 (27.1%) | 261 (33.2%) | 225 (32.3%) | 535 (30.2%) |
| 60 to <80 mmol/L | 87 (16.2%) | 20 (2.5%) | 36 (5.2%) | 117 (6.6%) |
| 30 to <60 mmol/L | 84 (15.7%) | 1 (0.1%) | 22 (3.2%) | 50 (2.8%) |
| <30 mmol/L | 19 (3.5%) | 0 (0%) | 0 (0%) | 10 (0.6%) |
| Missing | 37 (6.9%) | 110 (14.0%) | 97 (13.9%) | 217 (12.3%) |
| Post-modulator sweat chloride | ||||
| Mean (SD) | 53.0 (26.5) | 80.6 (16.8) | 87.5 (18.7) | 44.6 (21.3) |
| Median (Min, Max) | 48.5 (9.0, 130 5) | 80.5 (27.0, 133.5) | 91.0 (10.0, 123.0) | 42.0 (9.0, 129.0) |
| Category, n (%) | ||||
| 110+ mmol/L | 10 (1.9%) | 29 (3.7%) | 45 (6.5%) | 8 (0.5%) |
| 100 to <110 mmol/L | 18 (3.4%) | 63 (8.0%) | 120 (17.2%) | 24 (1.4%) |
| 80 to <100 mmol/L | 77 (14.4%) | 326 (41.5%) | 361 (51.8%) | 95 (5.4%) |
| 60 to <80 mmol/L | 87 (16.2%) | 282 (35.9%) | 123 (17.6%) | 243 (13.7%) |
| 30 to <60 mmol/L | 231 (43.1%) | 84 (10.7%) | 26 (3.7%) | 939 (53.1%) |
| <30 mmol/L | 113 (21.1%) | 1 (0.1%) | 22 (3.2%) | 460 (26.0%) |
| Post-modulator ppFEVl | ||||
| Mean (SD) | 88.4 (24.6) | 82.5 (21.8) | 76.7 (25.9) | 88.3 (23.7) |
| Median (Min, Max) | 93.2 (23.8, 137.1) | 87.6 (23.1, 129.9) | 81.4 (9.6, 132.5) | 93.3 (17.5, 139.5) |
| Category, n (%) | ||||
| 100+ | 179 (33.4%) | 145 (18.5%) | 132 (18.9%) | 618 (34.9%) |
| 70 to <100 | 185 (34.5%) | 378 (48.2%) | 306 (43.9%) | 735 (41.5%) |
| 40 to <70 | 71 (13.2%) | 149 (19.0%) | 167 (24.0%) | 310 (17.5%) |
| <40 | 27 (5.0%) | 34 (4.3%) | 82 (11.8%) | 73 (4.1%) |
| Missing | 74 (13.8%) | 79 (10.1%) | 10 (1.4%) | 33 (1.9%) |