Figure 2.

Processing pipeline. Raw T1 and diffusion-weighted images were processed using Tractoflow and SET to generate raw tractograms. The Freesurfer surfaces calculated on native T1w images at t₀ were segmented into 249 cortical/subcortical regions. Resection masks delineated on native T1w images at t₁ and t₂ were registered in the MNI space and merged. The 249 labelled regions computed at t₀ were individually registered to t₁ and t₂ native T1w images while the merged masks in MNI space were registered to t₀, t₁ and t₂ native T1w images (transfer of labels). The labels and merged masks registered to the same T1 space were combined to exclude portions of labels falling within the resection cavity (exclusion of masked labels) and retain unresected and hence included labels. The included labels and the raw tractograms were used by Connectoflow to derive COMMIT-weighted structural connectivity matrices. GM, gray matter.