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Results of the comprehensive BER pathway simulation. The concentration of repaired uracil sites and 8-oxoG lesions is shown for 200 nM of initial damage. Assuming a cell nucleus diameter of 5 µm, this corresponds to eight damage sites per cell. The results for models without cooperativity, with Ape1–Ogg1 and/or Ape1–Polβ dRp lyase cooperativity are shown.
