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. 2017 Dec 13;7:1–5. doi: 10.1016/j.clinms.2017.12.001

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© 2017 The Association for Mass Spectrometry: Applications to the Clinical Lab (MSACL). Published by Elsevier B.V.

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Fig. 1 — (a): The total ion chromatography of the urine steroid metabolome of this patient. The main peaks in this profile are the internal standard (androstanol, ISTD at 13.38 min), androsterone (A, 16.96 min), etiocholanolone (E, 17.18 min), 17-hydroxyprenanolone (17-OHPN, 19.61 min), pregnanetriol (PT, 20.88 min), tetrahydro 11-deoxycortisol (THS, markedly elevated at 21.85 min), hexahydro11-deoxycortisol (HHS at 23.02 and 23.16 min), tetrahydro cortisone (THE, 23.42 min) and tetrahydro cortisol (THF, supressed levels at 23.93 min). (b): Ion profile inside the TIC peak at 21.86 min. This EI fragmentation pattern demonstrates the presence of THS (based on the retention time and library match). THS chemical name is 5b-P-3a, 17a,21-TRIOL-20-ONE and molecular weight is 350.492 Da (g/mol). The major ions of THS are 246, 294, 384, 474 and 564.

Fig. 1 — (a): The total ion chromatography of the urine steroid metabolome of this patient. The main peaks in this profile are the internal standard (androstanol, ISTD at 13.38 min), androsterone (A, 16.96 min), etiocholanolone (E, 17.18 min), 17-hydroxyprenanolone (17-OHPN, 19.61 min), pregnanetriol (PT, 20.88 min), tetrahydro 11-deoxycortisol (THS, markedly elevated at 21.85 min), hexahydro11-deoxycortisol (HHS at 23.02 and 23.16 min), tetrahydro cortisone (THE, 23.42 min) and tetrahydro cortisol (THF, supressed levels at 23.93 min). (b): Ion profile inside the TIC peak at 21.86 min. This EI fragmentation pattern demonstrates the presence of THS (based on the retention time and library match). THS chemical name is 5b-P-3a, 17a,21-TRIOL-20-ONE and molecular weight is 350.492 Da (g/mol). The major ions of THS are 246, 294, 384, 474 and 564.