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. 2024 Jul 31;14:1425367. doi: 10.3389/fcimb.2024.1425367

Figure 3.

Figure 3

PGRN promotes the intracellular colonization of H. pylori. (A) qRT-PCR analysis of 16S rRNA in BGC-823 and GES-1 cells infected with H. pylori for 6 h, 12 h (n=3). (B) CFU analysis in BGC-823 and GES-1 cells infected with H. pylori (MOI = 100) for 3, 6, 12 and 24 h, then followed with gentamicin protection assay. (C) qRT-PCR analysis of PGRN mRNA expression level in BGC-823 and GES-1 cells transfected with PGRN siRNA or WT PGRN (n=3). (D) CFU analysis in BGC-823 cells transfected with PGRN siRNA or WT PGRN following H. pylori infection for indicated times, then followed with gentamicin protection assay (n=3). (E) qRT-PCR analysis of 16S rRNA levels in BGC-823 and GES-1 cells transfected with PGRN siRNA or WT PGRN following H. pylori infection for 6 h, 12 h (n=3). (*P<0.05, **P<0.01, ***P<0.001).