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. 2024 Jul 31;14:1425367. doi: 10.3389/fcimb.2024.1425367

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Copyright © 2024 Liu, Xiang, Zhou, Ren, Shi, Du, Fu, Li and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PGRN suppresses H. pylori-induced autophagy via down-regulation of DCN. (A) Gene microarray analysis of PGRN downstream target genes shown as volcano plots. (B) Western blot of DCN in BGC-823 cells transfected with WT PGRN and PGRN siRNA. (C) Western blot of DCN in BGC-823 cells transfected with DCN siRNA. (D) Western blot of LC3B in BGC-823 cells transfected with DCN siRNA following H. pylori infection for 12 h. (E) Western blot of LC3B in BGC-823 cells transfected with PGRN or/and DCN siRNA. (F) qRT-PCR analysis of 16S rRNA levels in BGC-823 cells transfected with DCN siRNA following H. pylori infection for 12 h (n=3). (G) qRT-PCR analysis of 16S rRNA levels in BGC-823 cells transfected with DCN siRNA, PGRN siRNA following H. pylori infection for 6, 12 h (n=3). (*P<0.05, **P<0.01, ***P<0.001, ns, not significant).