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PGRN down-regulates DCN by inhibiting the mTOR pathway. (A) GSEA analyzed the involvement of PGRN in the mTOR pathway. (B) Western blot of mTOR signaling in BGC-823 cells transfected with PGRN siRNA or WT PGRN. (C) Western blot of DCN in BGC-823 cells transfected with PGRN siRNA or WT PGRN, then treated with Everolious (10 nM) for 2 h. (*P<0.05).
