TABLE 2.
Impact of procedural and sampling variables on diagnostic yield
| Variable | Diagnostic yield (95% CI) | p-value, R2 analogue# |
|---|---|---|
| GA versus sedation | 0.83 (0.81–0.85) versus 0.75 (0.69–0.80) | p=0.007 |
| ILD MDM prior to cryobiopsy versus no ILD MDM | 0.82 (0.8–0.84) versus 0.76 (0.72–0.81) | p=0.02 |
| 2.4 mm versus 1.9 mm size cryoprobe | 0.82 (0.77–0.87) versus 0.75 (0.71–0.79) | p=0.04 |
| Higher mean FVC (% pred) | Coefficient 0.0063 (0.0001–0.013) | p=0.046, R2=0.24 |
| Higher mean DLCO (% pred) | Coefficient 0.0063 (0.0001–0.013) | p=0.022, R2=0.35 |
| Single lobe versus one or more lobes | 0.74 (0.067–0.82) versus 0.81 (0.78–0.85) | p=0.08 |
| Mean number of biopsies | Coefficient −0.017 (−0.055–0.022) | p=0.40, R2=0.0 |
| Lower lobes targeted for biopsy versus not targeted | 0.81 (0.74–0.88) versus 0.79 (0.77–0.82) | p=0.61 |
| Review by a single pathologist versus >1 pathologist | 0.78 (0.71–0.85) versus 0.80 (0.72–0.89) | p=0.69 |
| DPLD versus non-DPLD (inclusion criteria) | 0.80 (0.75–0.85) versus 0.79 (0.77–0.82) | p=0.79 |
#: Reported for meta-regression analyses. DLCO: diffusing capacity for carbon monoxide; DPLD: diffuse parenchymal lung disease; FVC: forced vital capacity; GA: general anaesthesia; ILD: interstitial lung disease; MDM: multidisciplinary meeting.