TABLE 4.
Impact of procedural and sampling variables on moderate-to-severe bleeding
| Variable | Moderate-to-severe bleeding (95% CI) | p-value, R2 analogue# |
|---|---|---|
| 2.4 mm versus 1.9 mm size of cryoprobe | 0.12 (0.08–0.16) versus 0.05 (0.03–0.07) | p=0.001 |
| Use of BTS bleeding score versus non-BTS bleeding score | 0.07 (0.02–0.13) versus 0.13 (0.11–0.15) | p=0.04 |
| Mean age | Coefficient 0.0034 (−0.0006–0.0073) | p=0.097, R2=0.0 |
| GA versus sedation | 0.11 (0.08–0.13) versus 0.15 (0.1–0.2) | p=0.13 |
| Lower lobes targeted versus no lobes targeted | 0.15 (0.1–0.2) versus 0.12 (0.1–0.14) | p=0.23 |
| Mean DLCO | Coefficient −0.0038 (−0.01–0.0028) | p=0.26, R2=0.08 |
| Fluoroscopy (sole imaging guidance) versus no imaging guidance | 0.11 (0.09–0.13) versus 0.15 (0.08–0.22) | p=0.26 |
| Single lobe versus one or more lobe sampling | 0.16 (0.01–0.3) versus 0.08 (0.06–0.1) | p=0.29 |
| Mean number of biopsies | Coefficient 0.015 (−0.015–0.044) | p=0.33, R2=0.0 |
| Prophylactic EBB versus no EBB | 0.14 (0.11–0.18) versus 0.13 (0.08–0.18) | p=0.65 |
| Mean FVC | Coefficient −0.0001 (−0.0065–0.0062) | p=0.97, R2=0.0 |
#: Reported for meta-regression analyses. BTS: British Thoracic Society; DLCO: diffusing capacity for carbon monoxide; EBB: endobronchial blocker; FVC: forced vital capacity; GA: general anaesthesia.