In vitro α-glucosidase and α-amylase inhibitory activity of the synthesized compounds 4-((7-chloroquinolin-4-yl) amino) benzohydrazide Schiff bases (6a–6j).
| Comp. | Product | IC50 values (μM) ± SEM | |
|---|---|---|---|
| α-Glucosidase | α-Amylase assay | ||
| 6a |
|
27.43 ± 1.42 | 45.62 ± 2.01 |
| 6b |
|
19.37 ± 0.96 | 29.36 ± 3.24 |
| 6c |
|
12.95 ± 2.35 | 33.04 ± 1.83 |
| 6d |
|
43.76 ± 4.31 | 58.74 ± 3.01 |
| 6e |
|
31.42 ± 1.67 | 53. 06 ± 2.06 |
| 6f |
|
143.52 ± 2.98 | 78.63 ± 1.35 |
| 6g |
|
302.51 ± 2.12 | No inhibition |
| 6h |
|
748.35 ± 1.09 | No inhibition |
| 6i |
|
108.56 ± 3.16 | 65.48 ± 1.16 |
| 6j |
|
63.25 ± 0. 23 | 56.32 ± 3.14 |
| Acarbose | — | 25.41 ± 0.16 | 32.63 ± 1.07 |