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Biological imaging of BF2 formazanate dyes. (A) 3-pyridyl BF2 formazanate was used as pH sensor. (B) Asymmetrical BF2 formazanate dye connected to GHSR-1a-targeting peptide via click reaction and applied in cell imaging with confocal. (C) NIR-II organic nanoparticles served as highly efficient phototheranostic agents in the NIR-II bio window. (D) A series of novel BF2 formazanate NIR-II dyes exhibited excellent blond-brain barrier crossing capacity, which were used in brain imaging.
