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Synthesis of α-, γ- and ε-TAMEs.
Reagents and conditions: (i) SOCl2, DMF, reflux, 3 h; (ii) ROH, pyridine, THF, r.t., overnight; (iii) ROH, EDC, DMAP, THF, r.t., overnight; (iv) NaOAc, Ac2O, reflux, 24 h; (v) ROH, DIPEA, THF, r.t., overnight; vi) KOH, 325 °C, 20 min.
