Scheme 2.
Synthesis of α-TAME through α-TAMSE.
Reagents and conditions: (i) R3SiCl, DIPEA, THF, r.t., 2 h; (ii) TBAF, DCM, r.t., 3 h; (iii) TCFH, NMI, ROH, MeCN, r.t., overnight; (iv) 1 M HCl workup.
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