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. Author manuscript; available in PMC: 2024 Aug 14.
Published in final edited form as: Bioorg Chem. 2022 Sep 30;129:106184. doi: 10.1016/j.bioorg.2022.106184

Table 2.

Top 20 TAMEs based on FABP5/3 selectivity index (SI).

Entry TAME FABP5/3 SI FABP5 KI (μM) FABP5/7 SI

1 α-16 41.3 1.30 ± 0.28 16.7
2 α-21 36.2 1.75 ± 0.07 0.47
3 α-1 38.0 0.12 ± 0.02 4.5
4 γ-12 32.3 0.79 ± 0.08 7.0
5 α-12 26.9 0.87 ± 0.06 3.8
6 α-5 16.7 0.36 ± 0.05 1.6
7* L3 14.7 1.72 ± 0.12* 8.3
8 α-22 14.2 1.83 ± 0.27 4.2
9 α-8 13.0 0.59 ± 0.08 0.56
10 α-7 12.4 0.44 ± 0.05 4.5
11 α-2 11.7 0.29 ± 0.01 0.41
12 α-10 11.0 0.74 ± 0.06 0.95
13 α-6 9.8 0.41 ± 0.15 2.2
14 γ-9 9.0 0.89 ± 0.25 2.1
15 γ-6 5.4 1.26 ± 0.12 1.4
16 α-4 4.8 0.33 ± 0.06 2.9
17 α-9 4.7 0.72 ± 0.08 1.4
18 γ-102 4.2 1.39 ± 0.07 0.64
19 α-15 3.7 1.30 ± 0.09 0.68
20 γ-13 3.4 1.77 ± 0.02 2.0

Ki values represent an average ± S.E. of at least three independent experiments.

*

Ki values from Reference [34].