Table 2.
Number of First AIDS-OIs Diagnoses Among Patients by Treatment Era (San Francisco, 1981–2012)
| AIDS-OIa | AIDS-OIs Diagnoses, No. (%) |
|||
|---|---|---|---|---|
| Pre-ART Era 1981–1986 (n = 3002) | Mono/Dual-ART Era 1987–1996 (n = 14 097) | cART Era 1997–2012 (n = 3759) | Total 1981–2012 (N = 20 858)b | |
|
| ||||
| PCP | 1640 (54.59) | 5379 (38.16) | 1144 (30.43) | 8163 (39.13) |
| KS | 952 (31.69) | 2768 (19.64) | 475 (12.64) | 4195 (20.11) |
| HIV wasting syndrome | 35 (1.17) | 1365 (9.68) | 464 (12.34) | 1864 (8.94) |
| Esophageal candidiasis | 100 (3.33) | 910 (6.46) | 371 (9.87) | 1381 (6.62) |
| MAC, disseminated | 80 (2.66) | 834 (5.92) | 155 (4.12) | 1069 (5.12) |
| HIV encephalopathy | 35 (1.17) | 715 (5.07) | 182 (4.84) | 932 (4.47) |
| Cryptococcosis | 106 (3.53) | 558 (3.96) | 219 (5.83) | 883 (4.23) |
| Cryptosporidiosis | 64 (2.13) | 503 (3.57) | 127 (3.38) | 694 (3.33) |
| Immunoblastic lymphoma | 72 (2.40) | 449 (3.19) | 155 (4.12) | 676 (3.24) |
| CMV, nonretinitis | 91 (3.03) | 455 (3.23) | 97 (2.58) | 643 (3.08) |
| Recurrent pneumonia | 8 (0.27) | 307 (2.18) | 226 (6.01) | 541 (2.59) |
| Toxoplasmosis, brain | 60 (2.00) | 334 (2.37) | 64 (1.70) | 458 (2.20) |
| CMV, retinitis | 19 (0.63) | 378 (2.68) | 56 (1.49) | 453 (2.17) |
| M. tuberculosis, infection | ||||
| Pulmonary | 5 (0.17) | 291 (2.06) | 135 (3.59) | 431 (2.07) |
| Disseminated | 14 (0.47) | 210 (1.49) | 54 (1.44) | 278 (1.33) |
| Burkett lymphoma | 26 (0.87) | 144 (1.02) | 69 (1.84) | 239 (1.15) |
| PML | 16 (0.53) | 109 (0.77) | 26 (0.69) | 151 (0.72) |
| Herpes simplex | 49 (1.63) | 148 (1.05) | 54 (1.44) | 241 (1.16) |
| Mycobacterium other, disseminated | 9 (0.30) | 94 (0.67) | 20 (0.53) | 123 (0.59) |
| Primary brain lymphoma | 14 (0.47) | 81 (0.57) | 24 (0.64) | 119 (0.57) |
| Tracheal candidiasis | 7 (0.23) | 49 (0.35) | 30 (0.80) | 86 (0.41) |
| Histoplasmosis | 3 (0.10) | 60 (0.43) | 15 (0.40) | 78 (0.37) |
| Isosporiasis | 1 (0.03) | 27 (0.19) | 8 (0.21) | 36 (0.17) |
| Coccidioidomycosis | 2 (0.07) | 20 (0.14) | 10 (0.27) | 32 (0.15) |
| Salmonella septicemia | 3 (0.10) | 14 (0.10) | 2 (0.05) | 19 (0.09) |
| Invasive cervical cancer | 0 (0.00) | 4 (0.03) | 8 (0.21) | 12 (0.06) |
Abbreviations: AIDS-OI, AIDS-defining opportunistic illness; ART, antiretroviral therapy; cART, combination ART; CMV, cytomegalovirus; HIV, human immunodeficiency virus; KS, Kaposi sarcoma; MAC, Mycobacterium avium complex; M. tuberculosis, Mycobacterium tuberculosis; n, number of individual patients; PCP, Pneumocystis pneumonia; PML, progressive multifocal leukoencephalopathy.
The AIDS-OIs numbered 3411, 16 206 and 4190 in the three treatment eras, respectively, for a total of 23 807. Patients may have >1 initial AIDS-OI and diagnoses shown in this table are sorted in descending order of their total count during 1981–2012.
There were a total of 23 807 OIs reported for 20 858 unique patients.