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. Author manuscript; available in PMC: 2024 Aug 14.
Published in final edited form as: Vet Pathol. 2023 Jul 11;61(1):145–156. doi: 10.1177/03009858231183907

Figure 4.

Figure 4.

Chlamydia muridarum associated lesions in various tissues, NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ mice. (a) Nasal cavity. Neutrophilic rhinitis with luminal neutrophilic exudate. Hematoxylin and eosin stain (HE). (b) Nasal cavity. Chlamydia antigen within epithelial cells and in luminal exudate. Immunohistochemistry (IHC) for Chlamydia major outer membrane protein antigen (MOMP). (c) Nasopharynx. Neutrophilic nasopharyngitis with intraepithelial Chlamydial inclusions (CIs) (arrows). HE. (d) Nasopharynx. Chlamydia antigen within epithelial cells. IHC for MOMP. (e) Trachea. Neutrophilic, histiocytic, and lymphocytic tracheitis with intraepithelial CI (arrow) and epithelial hyperplasia. HE. (f) Trachea. Chlamydia antigen within epithelial cells. IHC for MOMP. (g) Uterus. Neutrophilic endometritis with epithelial cell apoptosis and intralesional CI (arrow). HE. (h) Uterus. CI in epithelial cells lining the uterus. ISH for Chlamydia RNA. (i) Oviduct. Neutrophilic salpingitis with CI (arrows). HE. (j) Oviduct. CI within epithelial cells and free nucleic acid in the oviduct lumen. ISH for Chlamydia RNA.