Table 1.
Signalment, exposure, pathologic findings, tissues with Chlamydia inclusions, and ancillary tests performed in NSG mice infected with Chlamydia muridarum.
| Case Number | Sex | Agea | Exposure | Microscopic Diagnoses | Complete Blood Count Findings | Tissues with Chlamydia Inclusions (IHC and/or ISH) | Ancillary Testing |
|---|---|---|---|---|---|---|---|
| 1 | F | 12 | C | Bronchointerstitial pneumonia; Typhlocolitis | LC, N | L, SI, LI, T, NP | Isolation, IHC, ISH, qPCR |
| 2 | F | 12 | C | Bronchointerstitial pneumonia; Typhlocolitis | LC, N | L, SI, LI, T, NP, NC, ET | IHC, ISH |
| 3 | F | 12 | C | Bronchointerstitial pneumonia; Typhlocolitis | LC, N, Mo | L, SI, LI, T, NP, NC | IHC, ISH, qPCR, IFA |
| 4 | F | 12 | C | Bronchointerstitial pneumonia | LC, N | L, SI, LI, T, NP, NC, ME | IHC, ISH, qPCR |
| 5 | F | 12 | C | Bronchointerstitial pneumonia; Rhinitis | LC, N, Mo | L, SI, LI, T, NP, NC | IHC, ISH |
| 6 | F | 9 | C | Bronchointerstitial pneumonia; Rhinitis; Endometritis; Vaginitis; Salpingitis | LC, N, Mo | L, SI, LI, T, NP, V, U, O | IHC, ISH, IFA |
| 7 | F | 9 | C | Bronchointerstitial pneumonia | LC, N, Mo | L, SI, LI, T, NP, NC, ME | IHC |
| 8 | M | 9 | B | Bronchointerstitial pneumonia; Nasopharyngitis | N | L, SI, LI, T, NC | IHC |
| 9 | M | 9 | B | Bronchointerstitial pneumonia; Tracheitis | LC, N, Mo | L, SI, LI, T, ME | IHC |
| 10 | M | 9 | B | Bronchointerstitial pneumonia; Nasopharyngitis; Tracheitis | LC, N, Mo | L, SI, LI, T, NP, ET | IHC |
| 11 | M | 9 | B | Bronchointerstitial pneumonia | NA | L, SI, LI, T, NP, ET | IHC |
| 12 | F | 9 | C | Bronchointerstitial pneumonia; Rhinitis | LC, N, Mo | L, SI, LI, T, NC, ET | IHC |
| 13 | F | 9 | C | Bronchointerstitial pneumonia; Nasopharyngitis | NSF | L, SI, LI, T, NP | IHC, qPCR |
| 14 | M | 9 | B | Bronchointerstitial pneumonia; Nasopharyngitis | LC, N, Mo | L, SI, LI, T, NP | IHC, qPCR |
| 15 | M | 9 | B | Bronchiolitis; Nasopharyngitis; Tracheitis | LC, N | L, SI, LI, T, NP | IHC |
| 16 | M | 9 | B | Bronchointerstitial pneumonia; Nasopharyngitis | M | L, SI, LI, T, NP, ME | IHC |
| 17 | M | 9 | B | Bronchointerstitial pneumonia; Nasopharyngitis | LC, N, Mo | L, SI, LI, T, NP | IHC, qPCR |
| 18 | M | 9 | C | Bronchiolitis; Nasopharyngitis; Tracheitis | LC, N, Mo | L, SI, LI, T, NP, ME | IHC |
| 19 | M | 8 | C | Bronchointerstitial pneumonia; Nasopharyngitis | LC, N, Mo | L, SI, LI, T, NP, ME | IHC, qPCR, IFA, TEM |
Abbreviations: NSG, NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ; IHC, immunohistochemistry; ISH, in situ hybridization; qPCR, quantitative polymerase chain reaction; F, female; C, cohousing; LC, leukocytosis; N, neutrophilia; L, lung; SI, small intestine; LI, large intestine; T, trachea; NP, nasopharynx; NC, nasal cavity; ET, Eustachian tube; Mo, monocytosis; IFA, indirect immunofluorescence assay; ME, middle ear; V, vagina; U, uterus; O, oviduct; M, male; B, soiled bedding; NA, not applicable; NSF, no significant findings; TEM, transmission electron microscopy.
a
At euthanasia (months).