Table 2.
Antibiotic resistance rates and quinolone co-resistance of the different Shigella species
| Antibiotic |
Shigella sonnei n = 53 (55.8%) |
Shigella flexneri n = 39 (41.1%) |
Shigella boydii n = 3 (0.32%) |
Total n = 95 (100.0%) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| S | I | R | S | I | R | S | I | R | S | I | R | |
| n (%) | n (%) | n (%) | n (%) | |||||||||
| Ciprofloxacin | 32 (60.4) | 2 (3.8) | 19 (35.8) | 26 (66.7) | 2(5.1) | 11 (28.2) | 3 (100.0) | 0 (0.0) | 0 (0.0) | 61 (64.2) | 4 (4.2) | 30 (31.6) |
| Levofloxacin | 38 (71.7) | 3 (5.7) | 12 (22.6) | 26 (66.7) | 0 (0.0) | 13 (33.3) | 3 (100.0) | 0 (0.0) | 0 (0.0) | 67 (70.5) | 3 (3.2) | 25 (26.3) |
| Gatifloxacin | 43 (81.1) | 3 (5.7) | 7 (13.2) | 31 (79.5) | 0 (0.0) | 8 (20.5) | 3 (100.0) | 0 (0.0) | 0 (0.0) | 77 (81.1) | 3 (3.2) | 15 (15.8) |
| Ofloxacin | 37 (69.8) | 1 (1.9) | 15 (28.3) | 27 (69.2) | 0 (0.0) | 12 (30.8) | 3 (100.0) | 0 (0.0) | 0 (0.0) | 67 (70.5) | 1 (1.1) | 27 (28.4) |
| Imipenem | 53 (100.0) | 0 (0.0) | 0 (0.0) | 38 (97.4) | 0 (0.0) | 1 (2.6) | 3 (100.0) | 0 (0.0) | 0 (0.0) | 94 (98.9) | 0 (0.0) | 1 (1.1) |
| Meropenem | 52 (98.1) | 0 (0.0) | 1 (1.9) | 38 (97.4) | 0 (0.0) | 1 (2.6) | 3 (100.0) | 0 (0.0) | 0 (0.0) | 93 (97.9) | 0 (0.0) | 2 (2.1) |
| Ampicillin | 4 (7.5) | 1 (1.9) | 48 (90.6) | 1 (2.6) | 1 (2.6) | 37 (94.9) | 0 (0.0) | 0 (0.0) | 3 (100.0) | 5 (5.3) | 2 (2.1) | 88 (92.6) |
| Amoxicillin/clavulanic acid | 6 (11.3) | 0 (0.0) | 47 (88.7) | 8 (20.5) | 0 (0.0) | 31 (79.5) | 0 (0.0) | 0 (0.0) | 3 (100.0) | 14 (14.7) | 0 (0.0) | 81 (85.3) |
| Azithromycin | 32 (60.4) | 3 (5.7) | 18 (34.0) | 21 (53.8) | 3 (7.7) | 15 (38.5) | 2 (66.7) | 0 (0.0) | 1 (33.3) | 55 (57.9) | 6 (6.3) | 34 (35.8) |
| Cefotaxime | 25 (47.2) | 3 (5.7) | 25 (47.2) | 17 (43.6) | 2 (5.1) | 20 (51.3) | 0 (0.0) | 0 (0.0) | 3 (100) | 42 (44.2) | 5 (5.3) | 48 (50.5) |
| Ceftriaxone | 22 (41.5) | 4 (7.5) | 27 (50.9) | 13 (33.3) | 1 (2.6) | 25 (64.1) | 1 (33.3) | 0 (0.0) | 2 (66.7) | 36 (37.9) | 5 (5.3) | 54 (56.8) |
| Ceftazidime | 26 (49.1) | 1 (1.9) | 26 (49.1) | 17 (43.6) | 3 (7.7) | 19 (48.7) | 1 (33.3) | 0 (0.0) | 2 (66.7) | 44 (46.3) | 4 (4.2) | 47 (49.5) |
| Tetracycline | 34 (64.2) | 2 (3.8) | 17 (32.1) | 25 (64.1) | 2 (5.1) | 12 (30.8) | 1 (33.3) | 2 (66.7) | 0 (0.0) | 60 (63.2) | 6 (6.3) | 29 (30.5) |
| Chloramphenicol | 39 (73.6) | 0 (0) | 14 (26.4) | 27 (69.2) | 0 (0.0) | 12 (30.8) | 3 (100) | 0 (0.0) | 0 (0.0) | 69 (72.6) | 0 (0.0) | 26 (27.4) |
| Trimethoprim/sulfamethoxazole | 13 (24.5) | 2 (3.8) | 38 (71.7) | 7 (17.9) | 0 (0.0) | 32 (82.1) | 0 (0.0) | 0 (0.0) | 3 (100.0) | 20 (21.1) | 2 (2.1) | 73 (76.8) |
| Cefepime | 24 (45.3) | 7 (13.2) | 22 (41.5) | 14 (35.9) | 1 (2.6) | 24 (61.5) | 3 (100.0) | 0 (0.0) | 0 (0.0) | 41 (43.2) | 8 (8.4) | 45 (47.4) |
| Quinolone co-resistance in quinolone-resistant Shigella species |
Shigella sonnei n = 26 (61.9%) n (%) |
Shigella flexneri n = 16 (38.1%) n (%) |
Total n = 42 (100.0%) n (%) |
|---|---|---|---|
| Ciprofloxacin–levofloxacin | 5 (19.2) | 4 (25.0) | 9 (21.4) |
| Ciprofloxacin–ofloxacin | 2 (7.7) | 1 (6.3) | 3 (7.1) |
| Ciprofloxacin–gatifloxacin | 1 (3.8) | 0 (0.0) | 1 (2.4) |
| Levofloxacin–ofloxacin | 7 (26.9) | 3 (18.8) | 10 (23.8) |
| Gatifloxacin–ofloxacin | 6 (23.1) | 2 (12.5) | 8 (19.0) |
| Ciprofloxacin–levofloxacin–ofloxacin | 3 (11.5) | 1 (6.3) | 4 (9.5) |
| Ciprofloxacin–gatifloxacin–ofloxacin | 3 (11.5) | 0 (0.0) | 3 (7.1) |
| Levofloxacin–gatifloxacin–ofloxacin | 0 (0.0) | 1 (6.3) | 1 (2.4) |
| Ciprofloxacin–levofloxacin–gatifloxacin–ofloxacin | 0 (0.0) | 5 (31.3) | 5 (11.9) |