FIG. 4.

Representative aortic lesions and scores from control and cidofovir-treated mice. γHV68-infected IFN-γR^−/− mice were treated with either PBS or cidofovir beginning at 24 days postinfection, as described in Materials and Methods. (A) Lesion with a score of 5 from a PBS-treated control mouse that died 6 weeks postinfection. (B) Representative lesion with a score of 2 from a cidofovir-treated mouse that was sacrificed after 8.5 weeks of therapy. (C and D) Representative lesions with scores of 1 from cidofovir-treated mice that were sacrificed after 8.5 weeks of therapy. Note the noninflammatory intimal thickening in panels B, C, and D. Adv, adventitia; M, media; I, intima; L, lumen.